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澶嶅悎鏉愭枡
褰撳墠浣嶇疆錛?棣栭〉 >> 璧勮 >> 澶嶅悎鏉愭枡 >> 琛屼笟鍔ㄦ?/a> >> 姝ｆ枃

鍒跺墏宸ヤ綔鑰呭埄鐢ㄨ偪鐦ゅ井鐜鍏鋒湁浣?/span>pH銆?/span>楂?/span>H2O2鍜岄珮琛ㄨ揪鐨勭壒寮傛у彈浣撶瓑鐗瑰緛錛屾瀯寤?/span>pH/H2O2鏁忔劅鍜岄拡瀵?/span>楂?/span>琛ㄨ揪鑲跨槫鐗瑰紓鎬у彈浣撶殑澶氬姛鑳界撼綾寵嵂鐗╅掗佸鉤鍙幫紝鏃ㄥ湪灝嗚嵂鐗╂湁鏁堥澏鍚戦掗佸埌鑲跨槫緇勭粐鎴栫粏鑳?yōu)锛屽疄鐜拌偪鐦ょ殑闈跺悜娌荤枟銆傛墜鎬т粙瀛旂綰崇背媯掓槸浠嬪瓟紜呮棤鏈烘潗鏂?/span>錛?/span>闄ゅ叿鏈夋棤鏈虹鏉愭枡鐨勫垰鎬ч鏋躲佽緝澶х殑姣旇緝闈㈢Н鍜屽瓟浣撶Н銆佸彲璋冭妭鐨勪粙瀛斿瓟閬撳拰琛ㄩ潰涓板瘜鐨勭閱囧熀絳変紭鐐瑰錛岃繕鎷ユ湁鎵嬫х壒寮傛у拰媯掔姸褰㈣矊鐨勬嫇鎵戝浼樺娍錛岀粡蹇呰鐨勫寲瀛︿慨楗板悗錛屽彲浠ュ疄鐜拌偪鐦ょ殑闈跺悜閫掗佸茍鐢ㄤ簬鑲跨槫鐨勬不鐤椼?/span>


榪戞棩錛?/span>娌堥槼鑽澶у鑽闄㈡潕涓夐福鏁欐巿璇鵑緇勫拰涓浗鍖葷澶у鏉庨工鐒惰棰樼粍鍦ㄣ?/span>ACS Applied Materials & Interfaces銆嬫湡鍒婁笂鍙戣〃浜嗛涓?/span>鈥?/span>pH/H2O2 Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy鈥?span style="font-family:瀹嬩綋;">鐨勭爺絀舵ц鏂囥傛枃涓瀯寤虹殑閫掕嵂緋葷粺鏄湪琛ㄩ潰鏄撲簬鍔熻兘鍖栫殑媯掔姸浠嬪瓟紜呯撼綾崇矑鐨勫熀紜涓婏紝灝嗚嫰紜奸吀棰戝摢閱囬叝瀚佹帴鍒版鐘朵粙瀛旂綰崇背綺掕〃闈紝璧嬩簣浠嬪瓟紜呯撼綾蟲鐨勬墜鎬у拰瀵?/span>H2O2鐨勬晱鎰熸э紝鍐嶅皢鎶楃檶鑽樋闇夌礌杞藉叆綰崇背綺掑瓙鐨勫瓟閬撲腑錛岀劧鍚庡湪綺掑瓙琛ㄩ潰鍖呰９浜嗛忔槑璐ㄩ吀-鐜硦綺懼叡鑱氱墿浣滀負鈥?/span>瓚呭垎瀛愬紑鍏?/span>鈥?/span>錛屽嵆鍙槻姝㈤樋闇夌礌榪囨棭閲婃斁鍙堣兘鍙祴浜堢矑瀛愪富鍔ㄩ澏鍚戞с傝緋葷粺鏄竴縐嶅畨鍏ㄣ佹湁鏁堢殑pH/H2O2 鍙岄噸鏁忔劅媯掔姸鎵嬫т粙瀛旂綰崇背閫掗佸鉤鍙幫紝鍏鋒湁涓誨姩闈跺悜鍜?/span>pH/H2O2鍙岄噸鏁忔劅鐨勫閲嶆姉鐧屼紭鍔褲傜爺絀剁粨鏋滆瘉鏄庯紝杞戒綋涓殑闃塊湁绱犲湪浣?/span>pH鑲跨槫寰幆澧冧笅鍘熶綅閲婅嵂錛屽悓鏃惰兘澶熸彁楂樿偪鐦ゅ井鐜鐨?/span>H2O2嫻撳害錛屾彁楂樼矑瀛愬湪鑲跨槫閮ㄤ綅H2O2鐨勬晱鎰熺壒鎬э紝鍙戞尌楂樻晥鎶楃檶鐨勪綔鐢ㄣ傝鐮旂┒浠庣郴緇熸瀯寤恒佽瘎浠峰埌緇嗚優(yōu)鍜屾暣浣撳姩鐗╁眰闈㈢殑緋誨垪鑽悊鑽晥鐮旂┒緇撴灉錛岃瘉鏄庤繖鏄埄鐢ㄨ偪鐦ゅ井鐜鐗瑰紓鎬ф瀯寤虹殑澶氬姛鑳芥棤鏈虹綰崇背鑽墿閫掗佸鉤鍙扮殑涓涓垚鍔熸渚嬶紝涓鴻偪鐦ら澏鍚戦掕嵂緋葷粺鐨勮璁′笌鏋勫緩鎻愪緵浜嗕竴涓柊鎬濊礬銆?/span>



紺烘剰鍥?/span>1. 錛?/span>A錛?/span>pH/H2O2 鍙岄噸鏁忔劅鎬?/span>HA-CD/DOX-PCMSRs鐨勫悎鎴愯礬寰勶紱錛?/span>B錛夐氳繃CD44鍙椾綋浠嬪鑲跨槫緇嗚優(yōu)鍐呭寲HA-CD/DOX-PCMSRs鍜?/span>璇ョ矑瀛?/span>鍦?/span>pH/H2O2鍙岄噸鍒烘縺鍥犲瓙浣滅敤涓嬮噴鏀捐嵂鐗╃殑鏈哄埗銆?/span>


鏈枃瑕佺偣



鍥?/span>1. HA-CD/DOX-PCMSRs鐨勮〃寰併傦紙A錛?/span>B錛?/span>IR璋卞浘錛涳紙C-E錛?/span>XPS鍏夌數(shù)瀛愯兘璋憋紱錛?/span>F錛?/span>BET絳夋俯綰匡紱錛?/span>G錛夊瓟寰勫垎甯冿紱錛?/span>H錛?/span>SAXS璋卞浘錛涳紙I錛?/span>TGA鏇茬嚎銆?/span>


鍥?/span>2. 杞戒綋鍏稿瀷鐨?/span>TEM鐓х墖錛?/span>A-C錛夊拰綺掑緞鍒嗗竷錛?/span>D錛夈?/span>


鍥?/span>3. 錛?/span>A錛夊湪H2O2嫻撳害鍒嗗埆涓?/span>0銆?/span>1.0銆?/span>2.0鍜?/span>10 mM鐨?/span>pH 7.4紓烽吀鐩愮紦鍐叉恫涓?/span>DOX-PCMSRs鐨勪綋澶栭噴鏀炬洸綰匡紱錛?/span>B錛夊湪H2O2嫻撳害鍒嗗埆涓?/span>0銆?/span>1.0銆?/span>2.0鍜?/span>10 mM鐨?/span>pH 7.4紓烽吀鐩愮紦鍐叉恫鎴栧惈鏈?/span>10 mM H2O2 鐨?/span>pH 5.0紓烽吀鐩愮紦鍐叉恫涓?/span>HA-CD/DOX-PCMSRs鐨勪綋澶栭噴鏀炬洸綰匡紱錛?/span>C錛夊湪pH 5.0錛?/span>pH 6.5 鍜?/span>pH 7.4鐨勭７閰哥洂緙撳啿娑蹭腑HA-CD/DOX-PCMSRs鐨勪綋澶栭噴鏀炬洸綰匡紱錛?/span>D錛変笌DOX銆?/span>PCMSRs銆?/span>DOX-PCMSRs鍜?/span>HA-CD/DOX-PCMSR鍏卞鑲茬殑3T3緇嗚優(yōu)鍜?/span>4T1緇嗚優(yōu)涓?/span>H2O2鐨勭浉瀵?/span>琛ㄨ揪銆?/span>


鍥?/span>4. HA瀵?/span>Cy5.5-HA-CD/DOX-PCMSRs鐨勭珵浜夋ф姂鍒剁爺絀躲?/span>4T1緇嗚優(yōu)錛堝厛涓?/span>HA鍏卞鑲?/span>2 h錛?/span>A錛夊拰NIH/3T3緇嗚優(yōu) 錛?/span>B錛変笌Cy5.5鏍囪鐨?HA-CD/DOX-PCMSRs 鍏卞鑲?/span>2 h鍜?/span>4 h鍚庣殑CLSM鐓?/span>鐗囥?/span>4T1緇嗚優(yōu)錛?/span>鍏?/span>涓?/span>HA鍏卞鑲?/span>2 h錛?/span>C錛夊拰NIH/3T3緇嗚優(yōu)錛?/span>D錛変笌Cy5.5-鏍囪鐨?/span>HA-CD/DOX-PCMSRs 鍏卞鑲?/span>2 h鍜?/span>4 h鍚庣殑嫻佸紡緇撴灉銆?/span>


鍥?/span>5. 錛?/span>A錛?/span>B錛?/span>NIH/3T3鍜?/span>4T1緇嗚優(yōu)涓?/span>DOX錛?/span>DOX-PCMSRs鍜?/span>HA-CD/DOX-PCMSRs 鍏卞鑲?/span> 24銆?48鍜?72 h鍚庣殑浣撳緇嗚優(yōu)姣掓э紱錛?/span>C錛?/span>4T1緇嗚優(yōu)涓?/span>DOX, DOX-PCMSRs鍜?HA-CD/DOX-PCMSRs鍏卞鑲?/span>24 h鍚庣殑媧?/span>/姝葷粏鑳?yōu)鍥剧墖锛涘Q?/span>D錛?/span>4T1緇嗚優(yōu)涓?/span>DOX, DOX-PCMSRs鍜?HA-CD/DOX-PCMSRs鍏卞鑲?/span>24 h鍚庣殑緇嗚優(yōu)鍑嬩骸緇撴灉銆?/span>


鍥?/span>6. HA-CD/DiR-PCMSRs鐨勭敓鐗╁垎甯冨拰鑲跨槫闈跺悜鎬с傦紙A錛夐潤鑴夋敞灝?/span>DiR-PCMSRs鍜?/span>HA-CD/DiR-PCMSRs鍚庯紝4T1鑲跨槫緇嗚優(yōu)鑽風槫灝忛紶鍦ㄤ笉鍚屾椂闂寸偣鐨勪綋鍐呮垚鍍忕収鐗囷紱錛?/span>B錛夐潤鑴夋敞灝?/span>DiR-PCMSRs鍜?/span>HA-CD/DiR-PCMSRs 24 h鍚庯紝紱諱綋鍣ㄥ畼鍜岃偪鐦ょ殑媧諱綋鎴愬儚鐓х墖錛涳紙C錛夐潤鑴夋敞灝?/span>DiR-PCMSRs鍜?/span>HA-CD/DiR-PCMSRs 24 h鍚庯紝涓昏鑴忓櫒鍜岀浣撶槫鍧椾腑DiR-PCMSRs鍜?/span>HA-CD/DiR-PCMSRs鐨勫崐瀹氶噺鑽у厜寮哄害銆?/span>


鍥?/span>7. HA-CD/DOX-PCMSRs瀵?/span>4T1緇嗚優(yōu)鑽風槫灝忛紶鐨勬姉鐧屼綔鐢ㄥ拰鐢熺墿瀹夊叏鎬ц瘎浼般傦紙A錛夋不鐤楁柟妗堬紱錛?/span>B錛夋暣涓不鐤楄繃紼嬬殑鑲跨槫鐢熼暱鏇茬嚎錛涳紙C錛夋不鐤楁湡闂磋嵎鐦ゅ皬榧犱綋閲嶇殑鍔ㄦ佸彉鍖栵紱錛?/span>D錛夊湪21澶╂不鐤楄繃紼嬩綘錛岀浣撹偪鐦ゅ拰騫沖潎鑲跨槫閲嶉噺鐨勫吀鍨嬪浘鐗囷紱錛?/span>F錛変笉鍚屾不鐤楃粍鑲跨槫緇勭粐鐨?/span>H&E鍜?/span>TUNEL鏌撹壊銆?/span>


娌堥槼鑽澶у鑽闄㈠崥澹敓鐮旂┒鐢?/span>鐜嬬帀緹?/span>涓鴻璁烘枃絎竴浣滆咃紝鐮旂┒寰楀埌鍥藉鑷劧縐戝鍩洪噾錛?/span>No. 81773672 鍜?/span>No. 81903550錛?/span>璧勫姪銆?/span>


鐩稿叧閾炬帴

https://doi.org/10.1021/acsami.1c08532

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